MENU Sanofi Logo

The Unisom Advantage

A Heritage Of Restful Sleep

When a stressful day gets in the way of a restful night, you need something that can help you fall asleep and wake up refreshed. You need Unisom, the #1 Doctor Recommended OTC Sleep Aid Brand.

Since 1978 millions of people have turned to Unisom. Unisom is safe, when used as directed, and non-habit forming. It’s even available in several forms – including softgels, tablets, melts and mini-capsules, and our sleep supplement gummies – so there’s a nighttime sleeping solution just right for you.

Unlike some over-the-counter brands, Unisom offers single active ingredient sleep-aids. If your only issue is “How do I sleep better?” you shouldn’t take a sleep-aid containing extra medicines. If you do, however, have sleep problems accompanied by minor aches and pains, Unisom has a product for that, too — Unisom PM Pain.


Ingredients in Sleep Aids

Unisom is proud to offer formulas with two active sleep-aid ingredients to choose from. Both Unisom ingredients are safe, when used as directed, for sleeplessness and help troubled sleepers get a good night’s sleep. Here’s a bit more about Unisom sleep aids and Simple Slumbers sleep supplement.

Diphenhydramine HCl

Dyphenhydramine HCl is the active sleep ingredient in Unisom SleepGels®, SleepMeltsTM, SleepMinisTM, and PM Pain. It works by blocking the effects of a natural occurring neurotransmitter made by your body called histamine. When histamine is reduced, you experience drowsiness, which allows you to both fall asleep faster and stay asleep.

Doxylamine Succinate

The active sleep ingredient used in Unisom SleepTabs® is clinically proven to help you fall asleep 33% faster.1 It works like diphenhydramine HCl by blocking histamine which causes you to get drowsy and fall asleep. Unisom is the only leading over-the-counter sleep aid brand that uses this fast-acting sleep ingredient.


Melatonin is the supplement ingredient in Unisom Simple Slumbers, our 100% drug-free sleep solution. Melatonin improves your quality of sleep by working with your body’s natural sleep cycle to physiologically signal the body that it is time to sleep — causing drowsiness and lowering body temperature. Melatonin promotes sleep in a way that resembles the natural onset of sleep, while maintaining normal sleep cycle. By providing 5 mg of melatonin, Unisom Simple Slumbers supplements the body’s natural sleep process to help you fall asleep.*


1 vs. control in a clinical study – Data on file with FDA in support of NDA

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

You are about to leave

Links to websites that are not under the control of Chattem, Inc. are provided for convenience of reference only and are not intended as an endorsement by Chattem of the organization or a warranty of any type regarding the information on the website.

Chattem does not and cannot review all communications and materials posted or uploaded to other websites and is not responsible for the content of these communications and materials.

Do you want to continue?


Chattem, Inc. is only responsible for web content produced in association with Chattem, Inc.