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The Unisom Advantage

A Heritage Of Restful Sleep

When a stressful day gets in the way of a restful night, you need something that can help you fall asleep and wake up refreshed. You need Unisom, the #1 Pharmacist Recommended OTC Sleep Aid Brand.1

Since 1978 millions of people have turned to Unisom. Unisom is safe, non-habit forming and offers two different formulas. It’s even available in several forms – including softgels, tablets, melts, mini-capsules, and liquid – so there’s a nighttime sleeping solution just right for you.

Unlike some over-the-counter brands, Unisom offers single active ingredient sleep-aids. If your only issue is “How do I sleep better?” you shouldn’t take a sleep-aid containing extra medicines. If you do, however, have sleep problems accompanied by minor aches and pains, Unisom has a product for that, too — Unisom PM Pain.


Ingredients in Sleep Aids

Unisom is proud to offer formulas with two distinct sleep-aid ingredients to choose from. Both Unisom ingredients are safe for sleeplessness, when used as directed, and help troubled sleepers fall asleep quickly. Here’s a bit more about Unisom active ingredients.

Diphenhydramine HCl

Dyphenhydramine HCl is the active ingredient in Unisom SleepGels®, SleepMeltsTM, SleepMinisTM, and PM Pain. It works by blocking the effects of a natural occurring neurotransmitter made by your body called histamine.2 When histamine is reduced, you experience drowsiness, which allows you to both fall asleep faster and stay asleep.

Doxylamine Succinate

The active ingredient used in Unisom SleepTabs® is clinically proven to help you fall asleep 33% faster.3 It works like diphenhydramine HCl, but instead of just blocking histamine, doxylamine succinate also blocks acetylcholine,4 which causes you to get drowsy and fall asleep. Unisom is the only leading over-the-counter sleep aid brand that uses this fast-acting sleep ingredient.


1 Pharmacy Times – OTC Survey, 2015
3 vs. control in a clinical study – Data on file with FDA in support of NDA

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