Unisom® PM Pain

Read Reviews

Fall asleep fast, and relieve aches and pains.

This dual-action formula helps you fall asleep and relieves minor aches that might keep you up at night. You'll wake up less and get the rest you need. That’s why Unisom® is the #1 doctor recommended OTC sleep-aid brand.

  • Sleep-aid and pain reliever
  • Fall asleep fast and relieve pain
  • Wake up less
  • Non-habit-forming
  • Safe when used as directed
Get a Coupon


30-count pack

More Sellers

Product Information

What is this product / Purpose?

Nighttime sleep-aid and pain reliever. Temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness.

How to use the product


Do not take more than directed (see overdose warning)

Adults and children 12 years and older:

  • take 1 caplet at bedtime
  • do not take more than 1 caplet of this product in 24 hours

Children under 12 years: do not use this adult product in children under 12 years of age, this will provide more than the recommended dose (overdose) and may cause liver damage.


Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take:

  • more than 4,000 mg of acetaminophen in 24 hours
  • with other drugs containing acetaminophen
  • 3 or more alcoholic drinks every day while using this product

Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:

  • skin reddening
  • blisters
  • rash

If a skin reaction occurs, stop use and seek medical help right away.

Do not use

  • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
  • in children under 12 years of age
  • with any other product containing diphenhydramine, even one used on skin
  • if you have ever had an allergic reaction to this product or any of its ingredients

Ask a doctor before use if you have

  • liver disease
  • a breathing problem such as emphysema or chronic bronchitis
  • glaucoma
  • trouble urinating due to an enlarged prostate gland

Ask a doctor or pharmacist before use if you are

  • taking the blood thinning drug warfarin
  • taking sedatives or tranquilizers

When using this product

  • drowsiness will occur
  • avoid alcoholic drinks
  • do not drive a motor vehicle or operate machinery

Stop use and ask a doctor if

  • sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of serious medical illness.
  • pain gets worse or lasts for more than 10 days
  • fever gets worse or lasts for more than 3 days
  • redness or swelling is present
  • new symptoms occur

These could be signs of a serious condition.

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children.

Overdose warning: Taking more than the recommended dose (overdose) may cause liver damage. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.


A woman blissfully sleeping

Active Ingredient

Acetaminophen 325 mg

Unisom® PM Pain contains acetaminophen, an analgesic pain reliever that eases minor aches and pains that might keep you up at night.

Diphenhydramine HCl 50 mg

Unisom® PM Pain contains diphenhydramine, a non-habit-forming antihistamine. It blocks the effects of histamine in the body, making you sleepy.

All Ingredients

Active ingredient: Acetaminophen 325 mg, Diphenhydramine HCl 50 mg

Purpose: Pain reliever, Nighttime sleep-aid

Inactive ingredients: blue 1 lake, croscarmellose sodium, dicalcium phosphate, hydroxypropylcellulose, hypromellose, magnesium silicate, magnesium stearate, microcrystalline cellulose, mineral oil, pregelatinized corn starch, PVP, silica, sodium carboxymethyl starch, stearic acid

Get a Better Night’s Sleep Guaranteed

Don’t face another sleepless night alone, get the sleep you deserve with Unisom. Fall asleep fast and wake up feeling refreshed with the #1 Doctor and Pharmacist recommended OTC sleep aid.

If you’re not completely satisfied, get your money back, guaranteed. Terms and conditions apply.

Learn more

Frequently Asked Questions

  • You may be able to use your HSA and FSA tax-preferred savings account to purchase Unisom® PM Pain. The passage of the CARES Act by Congress includes provisions to restore Over the Counter (OTC) eligibility under tax-preferred HSA and FSA accounts. Your plan details may vary, so save your receipt and check with your benefits or health provider for eligibility.

  • Unisom® PM Pain contains diphenhydramine HCl and acetaminophen. Diphenhydramine HCl works by blocking the effects of a naturally occurring neurotransmitter your body makes called histamine. When histamine is reduced, you experience drowsiness, which allows you to fall asleep faster and stay asleep. Acetaminophen provides temporary relief to minor aches and pains.

  • The Unisom® PM Pain caplet is designed to be taken whole and not crushed.

  • For adults and children 12 years of age and older, 1 caplet should be taken at bedtime, or as directed by a doctor. Do not exceed labeled dosing. Use only as directed.

  • You should speak directly with your healthcare professional before taking any Unisom® products with other sleep medications.

  • Unisom® PM Pain can be taken with or without food.

  • Side effects may include daytime drowsiness, dry mouth, dizziness, memory problems, and severe skin reactions with symptoms such as skin reddening, blisters, or rashes. If you experience any of these side effects, discontinue use and consult your doctor. See the drug facts on the product packaging for full warning information.

  • Do not use any Unisom® products after the labeled expiration date. Use all products only as directed.

  • If pregnant or breastfeeding, ask a health professional before use.

  • When using Unisom® PM Pain avoid alcoholic drinks. Refer to product labeling for complete warnings and directions for use.

  • Unisom® PM Pain does not contain any ingredients made from a gluten-containing grain (wheat, barley, or rye).

  • Due to the numerous suppliers of raw materials, we cannot guarantee that Unisom® PM Pain doesn't contain some type of animal origin.

  • No. Unisom® PM Pain is non-habit forming and safe when used as directed.

  • Yes, Unisom® PM Pain contains diphenhydramine, which is an antihistamine.

  • Unisom® SleepGels®, SleepMinis®, and SleepMelts® all contain diphenhydramine, while Unisom® SleepTabs® contains a different antihistamine, doxylamine succinate. Like SleepGels®, Minis®, and Melts®, Unisom® PM Pain contains diphenhydramine, but it also contains 200mg of acetaminophen to address minor pain while you sleep. Unisom Simple Slumbers® is drug-free and contains 5 mg of melatonin, plus passionflower, lemon balm, and Vitamin B6. All Unisom® products help you get to sleep faster. Use all products only as directed.

  • No. Your Unisom® PM Pain sleep aid is just that: a nighttime sleep aid. Although one of the active ingredients is an antihistamine, the dosing frequency and directions may differ between its sleep-aid use and the allergy use. Therefore, it is advised you speak to your doctor or healthcare professional regarding allergy symptoms.

  • Unisom® is for occasional sleeplessness only. If your sleeplessness persists for more than two weeks, consult your doctor. Sleeplessness may be a symptom of serious underlying medical illness.

  • Unisom® PM Pain helps troubled sleepers fall asleep fast. However, like any OTC aid, results may vary.

  • Unisom® PM Pain helps troubled sleepers fall asleep fast and wake up less during the night. However, like any OTC sleep aid, results may vary.

You might also like these other Unisom® products

Learn more about sleep and sleeplessness.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.