Unisom® SleepGels®

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Get a better night’s sleep with Unisom® SleepGels®.

Fall asleep faster, wake up less, and feel refreshed in the morning. That's why Unisom is the #1 doctor recommended OTC sleep-aid brand.

  • Fall asleep faster
  • Wake up less
  • Non-habit-forming
  • Safe when used as directed
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Product Information

What is this product / Purpose?

Nighttime sleep-aid

How to use the product


Adults and children 12 years of age and over: 1 softgel (50 mg) at bedtime if needed, or as directed by a doctor.


Do not use

  • for children under 12 years of age
  • with any other product containing diphenhydramine, even one used on skin

Ask a doctor before use if you have

  • a breathing problem such as emphysema or chronic bronchitis
  • glaucoma
  • trouble urinating due to an enlarged prostate gland

Ask a doctor or pharmacist before use if you are

  • taking sedatives or tranquilizers

When using this product

  • avoid alcoholic drinks

Stop use and ask a doctor if

  • sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness.

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away.


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Active Ingredient

Diphenhydramine HCl 50 mg

Unisom® SleepGels® contain diphenhydramine, a non-habit-forming antihistamine. It blocks the effects of histamine in the body, making you sleepy.

All Ingredients

Active ingredient: Diphenhydramine HCl 50 mg

Purpose: Nighttime sleep-aid

Inactive ingredients: blue 1, gelatin, glycerin, polyethylene glycol, polyvinyl acetate phthalate, propylene glycol, sorbitol, titanium dioxide, water

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Frequently Asked Questions

  • You may be able to use your HSA and FSA tax-preferred savings account to purchase Unisom® SleepGels®. The passage of the CARES Act by Congress includes provisions to restore Over the Counter (OTC) eligibility under tax-preferred HSA and FSA accounts. Your plan details may vary, so save your receipt and check with your benefits or health provider for eligibility.

  • Unisom® SleepGels® contains diphenhydramine HCl. It works by blocking the effects of a naturally occurring neurotransmitter your body makes called histamine. When histamine is reduced, you experience drowsiness, which allows you to fall asleep faster and stay asleep.

  • The Unisom® SleepGels® are designed to be taken whole and not crushed or split.

  • For adults and children 12 years of age and over, 1 softgel should be taken at bedtime if needed, or as directed by a doctor. Do not exceed labeled dosing. Use only as directed.

  • You should speak directly with your healthcare professional before taking any Unisom® products with other sleep medications.

  • Unisom® SleepGels® can be taken with or without food.

  • Potential side effects may include daytime drowsiness, dry mouth, dizziness, and memory problems. If you experience any of these side effects, discontinue use and consult your doctor. See drug facts on the product packaging for full warning information.

  • Do not use any Unisom® products after the labeled expiration date. Use all products only as directed.

  • If pregnant or breastfeeding, ask a health professional before use.

  • When using Unisom® PM Pain avoid alcoholic drinks. Refer to product labeling for complete warnings and directions for use.

  • Unisom® SleepGels® do not contain any ingredients made from a gluten-containing grain (wheat, barley, or rye).

  • The Unisom® SleepGels® contain gelatin, which is an animal by-product.

  • No. Unisom® SleepGels® are non-habit-forming and safe when used as directed.

  • Yes, Unisom® SleepGels® contains diphenhydramine which is an antihistamine. Unisom® SleepGels® should be used only as directed for relief of occasional sleeplessness.

  • Unisom® SleepGels®, SleepMinis®, and SleepMelts® all contain diphenhydramine, while Unisom® SleepTabs® contains a different antihistamine, doxylamine succinate. Like SleepGels®, Minis®, and Melts®, Unisom® PM Pain contains diphenhydramine, but it also contains 200mg of acetaminophen to address minor pain while you sleep. Unisom Simple Slumbers® is drug-free, and contains 5 mg of melatonin, plus passionflower, lemon balm, and Vitamin B6. All Unisom® products help you get to sleep faster. Use all products only as directed.

  • No. Your Unisom® nighttime sleep aid is just that: a nighttime sleep aid. Although the active ingredient is an antihistamine, the dosing frequency and directions may differ between its sleep-aid use and the allergy use. Therefore, it is advised you speak to your doctor or healthcare professional regarding allergy symptoms.

  • Unisom® is for occasional sleeplessness only. If your sleeplessness persists for more than two weeks, consult your doctor. Sleeplessness may be a symptom of serious underlying medical illness.

  • Unisom® SleepGels® help troubled sleepers fall asleep fast. However, like any OTC aid, results may vary.

  • Unisom® SleepGels® help troubled sleepers sleep soundly and wake refreshed. However, like any OTC aid, results may vary.

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†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.