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Frequently Asked Questions

What is the appropriate dose for Unisom?

For Unisom SleepGels®, SleepTabs® or PM Pain, please take one. If you are taking Unisom SleepMeltsTM or SleepMinisTM, please take two. For Unisom Simple Slumbers, please take two gummies. Always refer to the directions located on the back label of all Unisom products. We do not recommend any other dosage amounts.

Can I build up a tolerance and become resistant to Unisom products?

It is possible that after long-term use you could become resistant to the sedation (sleepiness) from Unisom. However, the package states that you should not use Unisom for sleep for more than 14 days unless recommended by your doctor, for OTC Sleep Aid Products.

What are the Unisom active ingredients?

SleepGels: The active sleep-aid ingredient is diphenhydramine HCl (50 mg/dose).
SleepTabs: SleepTabs contain doxylamine succinate (25 mg/dose).
SleepMinis: The active sleep-aid ingredient is Diphenhydramine HCl (50 mg/dose).
SleepMelts: The active sleep-aid ingredient is diphenhydramine HCl (50 mg/dose).
PM Pain: The active sleep-aid ingredient is diphenhydramine HCl (50 mg/dose).  PM Pain also contains the pain reliever acetaminophen (325 mg/dose).
Simple Slumbers: The supplement ingredient is melatonin (5 mg/dose).

Will I become addicted to Unisom?

No. The products are non-habit forming and safe when used as directed.

What are the potential side effects of taking Unisom?

Potential Unisom side effects for diphenhydramine HCl and doxylamine succinate products are similar and might include daytime drowsiness, dry mouth, dizziness, and memory problems.1 If you experience any of these side effects, discontinue use and consult your doctor. See each product’s drug facts for full warning information.

Can I take Unisom for an allergy?

No. Your Unisom nighttime sleep aid is just that: a nighttime sleep aid. Although the active ingredient is an antihistamine, the dosing frequency and directions may differ between its sleep-aid use and the allergy use.  Therefore, it is advised you speak to your doctor or healthcare professional regarding allergy symptoms.

Is Unisom safe when used as directed and effective?

All Unisom formulas are safe when used as directed.

What sizes are available?

Unisom SleepTabs are available in 16, 32, 48 and 80 count sizes. All sizes are in child-resistant packaging. The 16 count is packaged in a blister card. All other sizes are available in bottles.
Unisom SleepGels are available in 8, 16, 32, 60 and 100 count sizes. All sizes are in child-resistant packaging. The 8 and 16 count are packaged in blister cards. All other sizes are available in bottles.
Unisom SleepMinis are available in a 60 count child-resistant bottle.
Unisom SleepMelts are available in 24 count child-resistant blister cards.
Unisom PM Pain is available in 15 and 30 count child-resistant bottles.
Unisom Simple Slumbers is available in a 60 and 120 count child-resistant bottles.

Should I consult my doctor first?

Before using any OTC product, you should always read the back label to determine if you have any pre-existing medical conditions that require you to first consult your doctor.

Will Unisom interact with my medications?

If you are currently taking any other medication, we recommend consulting a doctor or pharmacist regarding possible drug interactions.

Can I take Unisom every night?

Unisom is for occasional sleeplessness only. If your sleeplessness persists for more than two weeks, consult your doctor. Sleeplessness may be a symptom of serious underlying medical illness.

Can I take Unisom if I wake up in the middle of the night?

It is recommended that you take Unisom SleepTabs 30 minutes before going to bed for the evening. Unisom SleepMinis, SleepGels, SleepMelts, PM Pain and Simple Slumbers should be taken at bedtime. Taking the product too late at night may cause some morning drowsiness.

When should I take Unisom?

SleepGels: For adults and children 12 years of age and over, 1 softgel should be taken at bedtime if needed, or as directed by a doctor.
SleepTabs: For adults 12 years of age and older, 1 tablet should be taken 30 minutes before going to bed, or as directed by a doctor
SleepMinis: For adults 12 years of age and older, 2 mini-capsules should be taken at bedtime if needed, or as directed by a doctor
SleepMelts: For adults and children 12 years of age and over, 2 tablets should be taken at bedtime if needed, or as directed by a doctor.
PM Pain: For adults and children 12 years of age and older, 1 caplet should be taken at bedtime, or as directed by a doctor.
Simple Slumbers: For adults and children 18 years of age or older, 2 gummies should be taken before bedtime, or as directed by a doctor.

How do Unisom products work?

Unisom SleepGels, SleepMelts, SleepMinis and PM Pain contain diphenhydramine HCl. It works by blocking the effects of a naturally occurring neurotransmitter your body makes called histamine. When histamine is reduced, you experience drowsiness, which allows you to fall asleep faster and stay asleep.

SleepTabs’ active ingredient, doxylamine succinate, is a non-habit forming antihistamine that blocks certain natural substances (histamine, acetylcholine) that your body makes. The lack of histamine causes you to get drowsy and fall asleep quicker. As a result, you’ll get a good night’s sleep from Unisom tablets.

Simple Slumbers is 100% drug free and contains 5 mg of melatonin for a good night’s sleep. Simple Slumbers contains a proprietary blend of melatonin with passionflower, lemonbalm, and vitamin B6. Melatonin provides a triple effect by allowing you to fall asleep fast, sleep soundly and wake refreshed. Melatonin works naturally with the body to regulate the sleep-wake cycle by physiologically signaling to the body that it is time to sleep—causing drowsiness and lowering body temperature. Melatonin promotes sleep in a way that resembles the natural onset of sleep—through quiet wakefulness to the sleeping state, while maintaining normal sleep cycle. By providing 5 mg of melatonin, Unisom Simple Slumbers supplements the body’s natural sleep process to help you fall asleep.*

How fast will Unisom products make me fall asleep?

While this varies with the individual, our study shows that Unisom SleepTabs help people with occasional sleeplessness to fall asleep 33% faster than without Unisom.**

Will I remain asleep all night if I take Unisom products?

Studies show that Unisom helps troubled sleepers sleep soundly through the night. However, like any OTC aid, results may vary.

Why does Unisom make my mouth dry?

This is a side effect of the antihistamine. When you stop taking Unisom, this side effect will go away.


** vs control in a clinical study – Data on file with FDA in support of NDA.
1 Mayo Clinic – Sleep-Aids: The Options

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