Unisom® SleepMelts®

Get a better night’s sleep with Unisom® SleepMelts®.

SleepMelts® will help you wake up feeling refreshed and recharged. Specially formulated to melt quickly in your mouth, you don’t even need water to take them. You will fall asleep fast, wake up less, and get the rest you need. That’s why Unisom® is the #1 doctor recommended OTC sleep-aid brand.

  • Fall asleep fast
  • Dissolves fast
  • No water needed
  • Non-habit-forming
  • Cherry flavored
  • Safe when used as directed

Cherry flavor icon



24-count pack

Product Information

What is this product / Purpose?

Nighttime sleep-aid

How to use the product


Adults and children 12 years of age and over: 2 tablets (25 mg each) at bedtime if needed, or as directed by a doctor.

  • place 2 tablets on tongue; tablets dissolve with water or without water
  • allow tablets to dissolve in mouth or chew before swallowing


Do not use

  • for children under 12 years of age
  • with any other product containing diphenhydramine, even one used on skin

Ask a doctor before use if you have

  • a breathing problem such as emphysema or chronic bronchitis
  • glaucoma
  • trouble urinating due to an enlarged prostate gland

Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers
When using this product

  • avoid alcoholic drinks

Stop use and ask a doctor if

  • sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness.

If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Other Information

Cherry flavor


A woman blissfully sleeping

Active Ingredient

Diphenhydramine HCl 25 mg

Unisom® SleepMelts® contain diphenhydramine, a non-habit-forming antihistamine. It blocks the effects of histamine in the body, making you sleepy.

All Ingredients

Active ingredient: Diphenhydramine HCl 25 mg

Purpose: Nighttime sleep-aid

Inactive ingredients: citric acid, ethylcellulose, flavor, hydroxypropyl cellulose, mannitol, microcrystalline cellulose, PVP, red 7, starch, sucralose, sucrose

Get a Better Night’s Sleep Guaranteed

Don’t face another sleepless night alone, get the sleep you deserve with Unisom. Fall asleep fast and wake up feeling refreshed with the #1 Doctor and Pharmacist recommended OTC sleep aid.

If you’re not completely satisfied, get your money back, guaranteed. Terms and conditions apply.

Frequently Asked Questions

  • You may be able to use your HSA and FSA tax-preferred savings account to purchase Unisom® SleepMelts®. The passage of the CARES Act by Congress includes provisions to restore Over the Counter (OTC) eligibility under tax-preferred HSA and FSA accounts. Your plan details may vary, so save your receipt and check with your benefits or health provider for eligibility.

  • Unisom® SleepMelts® contain diphenhydramine HCl. It works by blocking the effects of a naturally occurring neurotransmitter your body makes called histamine. When histamine is reduced, you experience drowsiness, which allows you to fall asleep faster and stay asleep.

  • Place two Unisom® SleepMelts® tablets on tongue. Allow tablets to dissolve in mouth or chew before swallowing.

  • For adults and children 12 years of age and over, 2 tablets should be taken at bedtime if needed, or as directed by a doctor. Do not exceed labeled dosing. Use only as directed.

  • You should speak directly with your healthcare professional before taking any Unisom® products with other sleep medications.

  • Place two tablets on tongue; tablets dissolve with or without water. Unisom® SleepMelts® can be taken with or without food.

  • Potential side effects may include daytime drowsiness, dry mouth, dizziness, and memory problems. If you experience any of these side effects, discontinue use and consult your doctor. See drug facts on the product packaging for full warning information.

  • Do not use any Unisom® products after the labeled expiration date. Use all products only as directed.

  • If pregnant or breastfeeding, ask a health professional before use.

  • When using Unisom® SleepMelts® avoid alcoholic drinks. Refer to product labeling for complete warnings and directions for use.

  • Unisom® SleepMelts® do not contain any ingredients made from a gluten-containing grain (wheat, barley, or rye).

  • Due to the numerous suppliers of raw materials, we cannot guarantee that Unisom® SleepMelts® don’t contain some type of animal origin.

  • No. Unisom® SleepMelts® are non-habit forming and safe when used as directed.

  • Yes, Unisom® SleepMelts® contains diphenhydramine which is an antihistamine. Unisom® SleepMelts® should be used only as directed for relief of occasional sleeplessness.

  • Unisom® SleepGels®, SleepMinis®, and SleepMelts® all contain diphenhydramine, while Unisom® SleepTabs® contains a different antihistamine, doxylamine succinate. Like SleepGels®, Minis®, and Melts®, Unisom® PM contains diphenhydramine, but it also contains 200mg of acetaminophen to address minor pain while you sleep. Unisom Simple Slumbers® is drug-free and contains 5 mg of Melatonin, plus passionflower, lemon balm and Vitamin B6. All Unisom® products help you get to sleep faster. Use all products only as directed.

  • No. Your Unisom® nighttime sleep aid is just that: a nighttime sleep aid. Although the active ingredient is an antihistamine, the dosing frequency and directions may differ between its sleep-aid use and the allergy use. Therefore, it is advised you speak to your doctor or healthcare professional regarding allergy symptoms.

  • Unisom® is for occasional sleeplessness only. If your sleeplessness persists for more than two weeks, consult your doctor. Sleeplessness may be a symptom of serious underlying medical illness.

  • Unisom® SleepMelts® help troubled sleepers fall asleep fast. However, like any OTC aid, results may vary.

  • Unisom® SleepMelts® help troubled sleepers sleep soundly and wake refreshed. However, like any OTC aid, results may vary.

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†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.