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Common Questions

What is the appropriate dose for Unisom?

For Unisom SleepGels®, SleepTabs® or PM Pain, please take one. If you are taking Unisom QuickMeltsTM, please take two. When taking Unisom Liquid, use the measuring cup provided to get the correct dosage (30mL). Always refer to the directions located on the back label of all Unisom products. We do not recommend any other dosage amounts.

Can I build up a tolerance and become resistant to Unisom products?

It is possible that after long-term use you could become resistant to the sedation (sleepiness) from Unisom. However, the package states that you should not use these products for more than 14 days unless recommended by your doctor.

What are the active ingredients in Unisom products?

SleepGels: The active sleep-aid ingredient is diphenhydramine HCl (50 mg/dose).
SleepTabs: SleepTabs contain doxylamine succinate (25 mg/dose).
Unisom Liquid: The active sleep-aid ingredient is diphenhydramine HCl (50 mg/dose or 30mL/dose).
QuickMelts: The active sleep-aid ingredient is diphenhydramine HCl (50 mg/dose).
PM Pain: The active sleep-aid ingredient is diphenhydramine HCl (50 mg/dose).  PM Pain also contains the pain reliever acetaminophen (325 mg/dose).

Will I become addicted to Unisom?

No. The products are non-habit forming when used as directed and considered GRAS/E (Generally Recognazed as Safe and Effective) by the U.S. Food and Administration.

What are the potential side effects of taking Unisom?

Potential side effects for diphenhydramine HCl and doxylamine succinate products are similar and might include daytime drowsiness, dry mouth, dizziness, and memory problems.1 If you experience any of these side effects, discontinue use and consult your doctor. See each product’s drug facts for full warning information.

Can I take Unisom for an allergy?

No.  Unisom sleep-aids are just that: nighttime sleep-aids.  Although the active ingredient is an antihistamine, the dosing frequency and directions differ between its sleep-aid use and the allergy use. Therefore, we advise that consumers purchase the appropriate  allergy products for treating allergies to ensure that the antihistamine product is used in the manner that is safe and effective for the purpose of treating allergies.

Are Unisom products safe and effective?

All Unisom formulas are considered GRAS/E (Generally Recognized as Safe and Effective) by the FDA.

What sizes are available?

Unisom SleepTabs are available in 16, 32, and 48 count blister cards. All sizes are in child-resistant packaging with the exception of the 16 count, which is packaged in an easy-to-open, non-child resistant blister card.
Unisom SleepGels are available in 8, 16, 32, and 60 count cartons. The 8 count product is the easy-to-open, non-child resistant size for this formula. All other sizes are available in child-resistant packaging.
Unisom QuickMelts are available in 24 count child-resistant blister cards.
Unisom PM Pain is available in 15 and 30 count child-resistant bottles.
Unisom Liquid comes in a 12 ounce child-resistant bottle.

Should I consult my doctor first?

Before using any OTC product, you should always read the back label to determine if you have any pre-existing medical conditions that require you to first consult your doctor.

Will Unisom interact with my medications?

If you are currently taking any other medication, we recommend consulting a doctor or pharmacist regarding possible drug interactions.

Can I take Unisom every night?

Unisom is for occasional sleeplessness only. If your sleeplessness persists for more than two weeks, consult your doctor. Sleeplessness may be a symptom of serious underlying medical illness.

Can I take Unisom if I wake up in the middle of the night?

It is recommended that you take Unisom SleepTabs 30 minutes before going to bed for the evening. Unisom Liquid, SleepGels, QuickMelts, and PM Pain should be taken at bedtime. Taking the product too late at night may cause some morning drowsiness.

When should I take Unisom?

SleepGels: For adults and children 12 years of age and over, 1 softgel should be taken at bedtime if needed, or as directed by a doctor.
SleepTabs: For adults 12 years of age and older, 1 tablet should be taken 30 minutes before going to bed, or as directed by a doctor
Unisom Liquid: For adults and children 12 years of age and older, 2 tablespoons (30mL) of Unisom Liquid should be taken at bedtime if needed, or as directed by a doctor.
QuickMelts: For adults and children 12 years of age and over, 2 tablets should be taken at bedtime if needed, or as directed by a doctor.
PM Pain: For adults and children 12 years of age and older, 1 caplet should be taken at bedtime, or as directed by a doctor.

How do Unisom products work?

Unisom Liquid, SleepGels, QuickMelts, and PM Pain contain diphenhydramine HCl. It works by blocking the effects of a naturally occurring neurotransmitter your body makes called histamine. When histamine is reduced, you experience drowsiness, which allows you to fall asleep faster and stay asleep.

SleepTabs’ active ingredient, doxylamine succinate, is a non-habit forming antihistamine that blocks certain natural substances (histamine, acetylcholine) that your body makes. The lack of histamine and acetylcholine causes you to get drowsy and fall asleep quicker. As a result, you get a sound and safe night’s sleep.

How fast will Unisom products make me fall asleep?

While this varies with the individual, our study shows that Unisom SleepTabs help people with occasional sleeplessness to fall asleep 33% faster than without Unisom.*

Will I remain asleep all night if I take Unisom products?

Studies show that Unisom helps troubled sleepers sleep soundly through the night. However, like any OTC aid, results may vary.

Why does Unisom make my mouth dry?

This is a side effect of the antihistamine. When you stop taking Unisom, this side effect will go away.

References:

* vs control in a clinical study – Data on file with FDA in support of NDA.
1 Mayo Clinic – Sleep-Aids: The Options

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